Biochemistry 674, Fall 2005

Biochemistry 674: Biochemistry of Nucleic Acids

Class time: 8 a.m. TuTh, Chem 0127

Office Hours: Weds. 1:00-2:00, Thurs. 1:00-2:00 Chem 2500A

Results for the term paper, final exam, and course overall.
Exam II curve is up, answer key on reserve in the library.
Movies of the first step of translation from molecular dynamics.
The nucleosome, both here and at the Molecule of the Month at the PDB.
The results and the answer key to exam I are available on line.
For the curious (not required), here are web sites for RNA structure, function, folding:
Structure of a psoralen crosslink.
This year's syllabus (PDF).
Study questions for required papers.These also include study questions on the oligo hybridization spreadsheet.
Class notes and papers (by login only). Includes copyrighted papers, answers to base pairing questions posed in class.

General Teaching Resources, including an animation of the growth of a helix from a base pair.
Oligonucleotide hybridization thermodynamics math.and the associated spreadsheet.
Diagrams sketching (1) replication-mediated homologous recombination and (2) recombination-mediated repair of replication forks are available under General Teaching Resources.
A Protein-DNA tutorial using Rasmol on the HTH, ZnF, bZIP, and TBP DNA binding domain motifs and their interactions with DNA.
A DNA tutorial on the structures of A and B form nucleic acids. This may require you to look at the discussion of how to run Rasmol from your computer.
A large collection of PDB files of RNA, DNA, RNA/DNA binding proteins, and protein-RNA/DNA complexes, downloaded from the Protein Data Bank Web site.
Some old Exams I and II and finals.

Last Modified 9/1/05