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The RXR/RAR receptor heterodimer can also recognize the DR1 site, as seen in 1DSZ. The C-terminal "T-box" of RXR interacts with RAR. The RAR/RXR can recognize different spacings, but on DR2 and DR5 the RXR is "upstream" instead of "downstream," so interactions are mediated by the C-terminal end of RAR.
Source: Khorasanizadeh and Rastinejad, TIBS (2001), 26, p. 384.
Structure from F.Rastinejad et al., EMBO J. (2000), 19, p. 1045.
Back to RXR homodimer
Go to the RXR/TR structure.
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