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The RXR/TR (thyroid receptor) receptor heterodimer recognizes only the DR4 site, as seen in 2NLL. RXR binds "upstream," as it usually does. Protein-protein contacts are formed between loop of the TR and the second ZN-binding module of RXR. The T-box of RXR is disordered and it is not in position to interact. The extended C-terminal "A helix" of TR interacts with DNA, conferring additional binding affinity and specificity.
Source: Khorasanizadeh and Rastinejad, TIBS (2001), 26, p. 384.
Structure from F.Rastinejad et al., Nature (1995), 375, p. 203.
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