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The RXR receptor binds 9-cis retinoic acid. Its DBD homodimerizes or else heterodimerizes with several other nuclear hormone receptors
in order to recognize binding sites with different spacing between AGGTCA half-sites (DR1-2-3-4-5). 1BY4 shows the structure of thr RXR/RXR homodimer
binding direct repeats on the DR1 site. The C-terminal "T-box" clearly has a different conformation in the two different monomers: they are arranged
head-to-tail rather than head-to-head like the GR. The free RXR has the T-box tucked up against the DBD.
Source: Khorasanizadeh and Rastinejad, TIBS (2001), 26, p. 384.
Structure from Q.Zhao, S.A.Chasse, S.Devarakonda, M.L.Sierk, B.Ahvazi,
and F.Rastinejad, J. Mol. Biol. (2000), 296, p. 509.
Back to 1R4R.pdb
Go to the RXR/RAR structure.
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