Biochemistry 674: Biochemistry of Nucleic Acids

Class time: 8 a.m. TuTh, Chem 2201

Office Hours: Weds.1:30-2:30, Thurs. 2-3 Chem 2505

What's Here?

• Results from Exam 2.
• Sketch of replication-mediated homologous recombination in E. coli.
• Results (finally) from Exam 1.
• This year's syllabus.
• A Protein-DNA tutorial using Rasmol on the HTH, ZnF, bZIP, and TBP DNA binding domain motifs and their interactions with DNA.
• A DNA tutorial on the structures of A and B form nucleic acids. This may require you to look at the discussion of how to run Rasmol from your computer.
• A large collection of PDB files of RNA, DNA, RNA/DNA binding proteins, and protein-RNA/DNA complexes, downloaded from the Protein Data Bank Web site.

• A recent article on web-based bioinformatics
• A lot more info on groove-binding drugs and many other structures, at the Dervan lab and Wemmer lab.

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