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Steven Rokita

Steven Rokita
phone: 301.405.1816
fax: 301.405.9376

Rokita Group

Chem. and Biochem. web site

Honors and Awards:

NIH Postdoctoral Fellowship, 1983 -1985

Catacosinos Young Investigator in Cancer Research,1988

University Exploratory Research Investigator, 1987 - 1990

Outstanding Invention (Copper-dependent recognition of DNA), 2002

Faculty Excellence in Research, College of Life Science, UM College Park, 2005

Faculty Excellence in Service, College of Life Sciences, UM College Park, 2006

Research Summary

Bioorganic chemistry and biochemistry. Nucleic acid structure and reactivity; therapeutic and toxicology aspects of DNA modification; redox processes in enzymology, enzyme mechanisms of dehalogenation; biomimetic reactions of nickel and copper and electron transfer in nucleic acids.

Recent Publications

Lei Li, Kenneth D. Karlin and Steven E. Rokita "Changing Selectivity of DNA Oxidation from Deoxyribose to Guanine by Ligand Design and a New Binuclear Copper Complex" J. Am. Chem. Soc. 2005, 127, 520-521.

Emily E. Weinert, Kristen Frankenfield and Steven E. Rokita "Time-dependent Evolution of Adducts Formed Between Deoxynucleosides and a Model Quinone Methide"Chem. Res. Toxicol. 2005, 18, 1364-1370.

Takeo Ito, Sunita Thyagarajan, Kenneth D. Karlin and Steven E. Rokita "Recognition of Guanines at a Double Helix-Coil Junction in DNA by a Trinuclear Copper Complex" Chem. Commun. 2005, 4812-4814.

Jessica E. Friedman, James A. Watson Jr., David W.-H. Lam and Steven E. Rokita "Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily" J. Biol. Chem. 2006, 281, 2812-2819.

Sunita Thyagarajan, N. N. Murthy, Amy Sargeant, Kenneth D. Karlin and Steven E. Rokita "Selective DNA Strand Scission with Binuclear Copper Complexes: Implications for the Involvement of a Cu2-O2 Active Species" J. Am. Chem. Soc. 2006, 128, 7003-7008.

Lei Li, Narasimha N. Murthy, Joshua Telser, Lev. N. Zakharov, Glenn P. A. Yap, Arnold L. Rheingold, Kenneth D. Karlin and Steven E. Rokita "Targeted Guanine Oxidation by a Dinuclear Copper(II) Complex a Single Stranded/Double Stranded DNA Junctions" Inorg. Chem., 2006, 45, 7144-7159.

Emily E. Weinert, Ruggero Dondi, Stefano Colloredo-Melz, Kristen N. Frankenfield, Charles H. Mitchell, Mauro Freccero and Steven E. Rokita "Substituents on Quinone Methides Strongly Modulate Formation and Stability of Their Nucleophilic Adducts" J. Am. Chem. Soc., 2006, 128, 11940-11947.

Matthew R. Holman, Takeo Ito, Steven E. Rokita "Self-repair of Thymine Dimer in Duplex DNA" J. Am. Chem. Soc. 2007, 129, 6-7.

Huan Wang, Manvinder S. Wahi and Steven E. Rokita "Immortalizing a Transient Electrophile for DNA Cross-linking" Angew. Chem. Int. Ed., in press. James A. Watson, Jr., Patrick M. McTamney, Jennifer M. Adler, and Steven E. Rokita "The Flavoprotein Iodotyrosine Deiodinase Functions without Cysteine Residues" ChemBioChem, in press.

Link to Publications at PubMed
Complete Publications PDF


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