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Douglas Julin

Douglas Julin
Associate Professor

djulin@umd.edu
phone: 301.405.1821
fax: 301.314.9121

Chem. and Biochem. web page

Detailed research description.

Research Summary

Mechanisms and structure of enzymes that act on DNA. Enzymology and mechanism of genetic recombination and DNA repair. Structure, function and mechanism of the RecBCD enzyme from Escherichia coli.

Recent Publications

Ghatak, A., and Julin, D. A. (2006) "Kinetics of ATP-stimulated nuclease activity of the Escherichia coli RecBCD enzyme." Journal of Molecular Biology 361, 954-968.

Wang, J., and Julin, D. A. (2004) "DNA Helicase Activity of the RecD Protein from Deinococcus radiodurans." Journal of Biological Chemistry 279, 52024-52032.

Kulkarni, A., and Julin, D. A. (2004) "Specific inhibition of the E. coli RecBCD enzyme by Chi sequences in single-stranded oligonucleotides." Nucleic Acids Research 32, 3672-3682.

Chang, H., and Julin, D. A. (2001) “Structure and Function of the E. coli RecE Protein, a Member of the RecB Nuclease Domain Family” Journal of Biological Chemistry 276, 46004-46010.

Wang, J., Chen, R., and Julin, D. A. (2000) "A Single Nuclease Active Site of the Escherichia coli RecBCD Enzyme Catalyzes Single-Stranded DNA Degradation in Both Directions." Journal of Biological Chemistry 275, 507-513.

 

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